Titration to a Therapeutic Dose May Lead to Greater Adherence
ثبت نشده
چکیده
Antiepileptic drugs (AEDs) including LYRICA increase the risk of suicidal thoughts or behavior in patients taking AEDs for any indication. Monitor patients treated with any AED for any indication for the emergence or worsening of depression, suicidal thoughts or behavior, and/or any unusual changes in mood or behavior. Pooled analysis showed clinical trial patients taking an AED had approximately twice the risk of suicidal thoughts or behavior than placebo-treated patients. The estimated incidence rate of suicidal behavior or ideation among 27,683 AED-treated patients was 0.43%, compared to 0.24% among 16,029 placebo-treated patients, representing an increase of approximately one patient for every 530 patients treated with an AED. Please see Full Prescribing Information and Medication Guide starting on page 5 of this PDF. 150 mg/day RECOMMENDED STARTING DOSE 300 mg/day maximum dose UP TO 450 mg/day maximum dose UP TO 600 mg/day maximum dose
منابع مشابه
THE COMPARATIVE STUDY OF ANTIHYPERTENSIVE TREATMENTS (CSAT): BACKGROUNDS, METHODS, AND THE PRELIMINARY RESULTS (INTERIM REPORT)
The "Comparative Study of Antihypertensive Treatments"-CSA T is a placebo-controlled, randomized, double-blind clinical trial, with the primary objective of comparing the efficacy of different pharmacological treatments of hypertension. Drug side-effects, patient compliance, and alterations in the patients' quality of life are also compared. Subjects with mild to moderate diastolic hyperte...
متن کاملFactors Affecting Treatment Adherence among HIV-Positive Patients in Eritrea
Strict adherence to anti-retroviral therapy (ART) is critical for sustained suppression of viral replication and prevention of opportunistic infections that often lead to disability or death. With increased availability of ART in recent years, achievement of optimal adherence has become very important in the management of HIV/AIDS in Eritrea. To assess the factors affecting adherence to ART of ...
متن کاملPhysician adherence to the dyslipidemia guidelines is as challenging an issue as patient adherence.
BACKGROUND A wide therapeutic gap exists between evidence-based guidelines and their practice in the primary care, which is primarily attributed to physician and patient adherence. OBJECTIVE This study aims to differentiate physician and patient adherence to dyslipidemia secondary prevention guidelines and various factors affecting it. METHODS A post hoc analysis of data collected by a pros...
متن کاملInteraction of lead acetate with calcium channel blockers in formalin test and formalin-induced inflammation
In this study interaction of three types of calcium channel blockers nifedipine, diltiazem and verapamil on the effects of lead acetate on two types of pain (nociception and inflammation) induced by formalin in mice were examined. In order to study nociception, formalin test was selected because of greater resemblance to clinical pain. Lead acetate (50, 75, l00, 125 and 150 mg/kg) administere...
متن کاملCumulative Risk Estimation for Chemical Mixtures
In reality, humans are always exposed to a combination of toxic substances and seldom to a single agent. Simultaneous exposure to a multitude of chemicals could result in unexpected consequences. The combined risk may lead to greater or less than a simple summation of the effects induced by chemicals given individually. Here, a method is proposed for estimating the cumulative risk which is the ...
متن کامل